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This article explores the escalating public health concern of emerging tick-borne infections in mainland China. As these infections pose a growing threat, a comprehensive examination of their epidemiological trends, implicated pathogens, and associated challenges is presented. The study also delves into the public health implications, diagnostic difficulties, and preventive measures essential for mitigating the impact. By identifying research gaps and emphasizing the need for collaborative efforts, this work aims to contribute to a better understanding and management of the evolving landscape of tick-borne infections in mainland China.