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Vaccination plays a crucial role in cancer prevention by targeting viruses that are known to cause certain types of cancer. This article provides a global epidemiological analysis of the impact of vaccines on cancer prevention, focusing on the human papillomavirus (HPV) and hepatitis B virus (HBV) vaccines. We examine the mechanisms through which these vaccines reduce cancer incidence, discuss the current state of vaccination programs worldwide, and highlight the challenges and opportunities for expanding vaccination coverage to further reduce the global cancer burden.